Young small extracellular vesicles rejuvenate replicative senescence by remodeling Drp1 translocation-mediated mitochondrial dynamics
Abstract Background Human mesenchymal stem cells have attracted interest in regenerative medicine and are being tested in many clinical trials.In vitro expansion is necessary to provide clinical-grade quantities of mesenchymal stem cells; however, it has Funko Pop! been reported to cause replicative senescence and undefined dysfunction in mesenchym